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James Lee

Headshot: James Lee

Assistant Professor - Pharmaceutical Sciences, School of Pharmacy

Office: Bunting 206

To schedule an appointment and/or general information, please contact: 
Department of Pharmaceutical Sciences 
410-532-5206

Education
Ph.D. Molecular Biology, University of Pennsylvania, Philadelphia, PA, 1990
B.S. Biological Sciences - SUNY Stony Brook, Stony Brook, NY, 1982

Research Interests
Use of natural products as anticancer agents, mechanism of toxicity of abused drugs, hormonal regulation of proteins involved in drug pharmacokinetics and pharmacodynamics. Alteration of gene expression by natural products and pain medications.

Publications
Moon KH, Upreti VV, Yu LR, Lee IJ, Ye X, Eddington ND, Veenstra TD, Song BJ. Mechanism of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-mediated mitochondrial dysfunction in rat liver. Proteomics. 2008 Sep;8(18):3906-18.

Upreti VV, Eddington ND, Moon KH, Song BJ, Lee IJ. Drug interaction between ethanol and 3,4-methylenedioxymethamphetamine ("ecstasy"). Toxicol Lett. 2009 Jul 24;188(2):167-72.

Teksin ZS, Lee IJ, Nemieboka NN, Othman AA, Upreti VV, Hassan HE, Syed SS, Prisinzano TE, Eddington ND. Evaluation of the transport, in vitro metabolism and pharmacokinetics of Salvinorin A, a potent hallucinogen. Eur J Pharm Biopharm. 2009 Jun;72(2):471-7.

Lee IJ, Hom K, Bai G, Shapiro M. NMR metabolomic analysis of caco-2 cell differentiation. J Proteome Res. 2009 Aug;8(8):4104-8.

Coles LD, Lee IJ, Hassan HE, Eddington ND. Distribution of saquinavir, methadone, and buprenorphine in maternal brain, placenta, and fetus during two different gestational stages of pregnancy in mice. J Pharm Sci. 2009 Aug;98(8):2832-46.

Coles LD, Lee IJ, Voulalas PJ, Eddington ND. Estradiol and progesterone-mediated regulation of P-gp in P-gp overexpressing cells (NCI-ADR-RES) and placental cells (JAR). Mol Pharm. 2009 Nov-Dec;6(6):1816-25.

Hassan HE, Myers AL, Lee IJ, Chen H, Coop A, Eddington ND. Regulation of gene expression in brain tissues of rats repeatedly treated by the highly abused opioid agonist, oxycodone: microarray profiling and gene mapping analysis.. Drug Metab Dispos. 2010 Jan;38(1):157-67.

Professional Affiliations & Memberships
American Association for the Advancement of Science
International Society for the Study of Xenobiotics
American Association for Cancer Research