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Paulo Carvalho

Headshot: Paulo Carvalho

Assistant Professor - Pharmaceutical Sciences, School of Pharmacy

Office: Bunting 205

To schedule an appointment and/or general information, please contact: 
Department of Pharmaceutical Sciences 
410-532-5206 

Education

Ph.D. Medicinal Chemistry - Universidade de Sao Paulo, USP, Sao Paulo, Brazil, 2001 
M.Sc. Medicinal Chemistry - Universidade de Sao Paulo, USP, Sao Paulo, Brazil, 1997 
BScPharmacy - Universidade de Sao Paulo, USP, Sao Paulo, Brazil, 1989


Research Interests

Synthesis of bioactive natural products, synthesis and biological evaluation of drugs against tropical diseases and anticancer drugs, development of analytical methods for identification of new chemical entities and quantification of drugs in biological fluids.

Selected Publications
Porta, E.O.J. et al. (2014). Click chemistry decoration of amino sterols as promising strategy to developed new leishmanicidal drugs. Steroids, 28-36.

Hammond, N. L.  et al. (2011). Synthesis and biological evaluation of a novel anti-malarial lead.Med Chem Res, 20, 401–407.

Ghiano, D. G. et al.  (2011). Solution synthesis of lavendustin analogs as antileishmanial agents. ARKIVOC (vii) 297-311.

Mizuno, C.S. et al. (2010). Design, Synthesis, and Docking Studies of Novel Benzimidazoles for the Treatment of Metabolic Syndrome J. Med. Chem. 53, 1076–1085.

Herath, H.M.T.B., et al. (2009) Biologically Active Tetranorditerpenoids from the Fungus Sclerotinia homoeocarpa Causal Agent of Dollar Spot in Turfgrass. J. Nat. Prod.,72 (12), 2091–2097.β

Jain, S. et al. (2009). Sipholane Triterpenoids: Chemistry, Reversal of ABCB1/P-Glycoprotein-Mediated Multidrug Resistance, and Pharmacophore Modeling.J. Nat. Prod. 72, 1291–1298.

Zhang, S-Q, et al. (2009). Determination of a novel epothilone D analog (AV-EPO-106) in human plasma using ultra-performance liquid chromatography–tandem mass spectrometry. Biom. Chromatography23(3),302–307.

Taranto, A.G. et al. (2008).QM/QM studies for Michael reaction in coronavirus main protease (3CLPro). J. Mol. Graphics and Modelling, 27(3), 275–285.


Carvalho, P.B..
et al. (2008).7β-Hydroxyartemisinin. Acta Cryst. E64, o395-o396.


Zhu, S.
et al. (2008). Simultaneous determination of benzo[a]pyrene and eight of its metabolites in Fundulus heteroclitus bile using ultra performance liquid

chromatography with mass  spectrometry.  J.  Chromatography  B,  863,(1),  141–149.

Li, L. et al. (2008). Ultra-performance liquid chromatography–tandem mass spectrometric method for the determination of Artemisinin in rat serum and its application in pharmacokinetics. J.Chromatography B, 867, (1), 131–137.

A.G.Chittiboyina, A. G. et al. (2007).Total synthesis and absolute configuration of Laurenditerpenol: A Hypoxia Inducible Factor-1 Activation Inhibitor. J. Med. Chem., 50 (25), 6299–6302.


Professional Affiliations & Memberships

American Association of Colleges of Pharmacy

American Association of Pharmaceutical Scientists

American Chemical Society

The Rho Chi Society