Ahmed M.

Abdel-Megied Ali

School of Pharmacy

Education

• Ph.D. in Pharmacy, Pharmaceutical Analytical Chemistry- Minia University, College of Pharmacy, Egypt, 2013.
• M.Sc. in Pharmacy, Pharmaceutical Analytical Chemistry- Minia University, College of Pharmacy, Egypt, 2009.
• B.S. Pharmacy, Minia University, College of Pharmacy, Egypt, 2003

• Postdoctoral Associate

Mass Spectrometry Center, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, USA.
Project: Rapid and Comprehensive Detection of SARS-CoV-2 Virus Envelope Lipids.
Advisor: Prof. Jace W. Jones.

• Postdoctoral Research Fellow

Pacific University Oregon, School of Pharmacy, Hillsboro, Oregon, USA.
Project:  Modulation of Arachidonic Acid Metabolism as a new target for the Treatment of Hypertension through high sensitivity LC-MS/MS bioanalytical method.
Advisor: Prof. Fawzy. Elbarbry.

• Postdoctoral Research Fellow

Institute of Medicinal and Pharmaceutical Chemistry, Technical University Braunschweig, (TUB), Braunschweig, Germany.
Project:  A binding affinity study for simultaneous determination of total and unbound deferiprone- Iron (III) complex using LC-ESI/MS and capillary electrophoresis/frontal analysis (CE/FA) methods.
Advisor: Prof. Hermann Wätzig and Prof. Sami El- Deeb.

Research Interests

• Drug Pharmacokinetics: Development new methods of analysis for determination of drugs either in pharmaceutical dosage forms or biological fluids using different separation techniques such as Capillary Electrophoresis (CE), HPLC, UPLC and HPTLC couples with different detectors such as PDA, fluorescence and mass spectrometry.
• Lipidomics and Metabolomics: Develop mass spectrometry-based platforms that couple biomarker discovery to quantitative validation via the use of chromatography, ion mobility, and mass spectrometry to structurally elucidate and quantify biologically active lipids to further understand disease/injury mechanism of action and provide novel insight for drug development targets.
• Bioanalysis in Clinical Research: Bioanalysis is the sub-discipline of analytical chemistry that deals with the qualitative & quantitative measurement of small molecules such as drugs, metabolites and, endogenous substances in complex biological samples. Optimization of sample preparation techniques using solid phase extraction and hyphenated chromatographic & electrophoretic techniques is carried out.

Google Scholar: https://tinyurl.com/54b7ynhn
ResearchGate: https://www.researchgate.net/profile/Ahmed_Abdel-Megied

Publications

• Ahmed M. Abdel‑Megied, Isaac A. Monreal, Limian Zhao, Alex Apffel, Hector C. Aguilar, Jace W. Jones “Characterization of the cellular lipid composition during SARS‑CoV‑2 infection” Anal Bioanal Chem. 2023. Accepted on July 2023. https://doi.org/10.1007/s00216-023-04825-1 (Q1, IF: 4.3).
• Galal Magdy, Amira A Al-Enna, Fathalla Belal, Ramadan A El-Domany, Ahmed M Abdel-Megied “Analytical quality-by-design approach for development and validation of HPLC method for the simultaneous estimation of omarigliptin, metformin, and ezetimibe: application to human plasma and dosage forms” BMC Chemistry. 2023, 17, 45. https://doi.org/10.1186/s13065-023-00955-w (Q2, IF: 4.6).
• Amira S Gouda, Hoda M Marzouk, Mamdouh R Rezk, Ahmed M Abdel-Megied “Ecofriendly stability-indicating UHPLC-PDA method for determination of the new influenza antiviral prodrug Baloxavir Marboxil; Application to degradation kinetic studies and structure elucidation of the major degradation products using LC-MS” Sust Chem & Pharm. 2023, 33, 101093. https://doi.org/10.1016/j.scp.2023.101093 (Q1, IF: 6.0).
• A Salem, A Gouda, H Marzouk, M Rezk, A M. Abdel-Megied “A Population Pharmacokinetic Modelling Approach to Evaluate the Current Dosing Recommendations of Favipiravir in Egyptian Subjects” Int J Infect Dis. 2023, 130, S94. https://doi.org/10.1016/j.ijid.2023.04.234 (Q1, IF: 12.0).
• Ahmed M Abdel‐Megied, Sergiy Kovalenko, Fawzy A Elbarbry, Marjan Piponski, Oleksandra Oleshchuk, Sami El Deeb, Galal Magdy, Fathalla Belal, Taras Grochovuy, Liliya Logoyda “LC‐MS/MS Bioanalytical Method for the Quantitative Analysis of Nifedipine, Bisoprolol, and Captopril in Human Plasma: Application to Pharmacokinetic Studies”. J Biomed Chromatogr. 2023; Online Record: e5664. https://doi.org/10.1002/bmc.5664 (Q2, IF: 1.8).
• Galal Magdy, Shaimaa Ebrahim, Fathalla Belal, Ramadan A El-Domany, and Ahmed M Abdel-Megied “Sulfur and nitrogen co-doped carbon quantum dots as fluorescent probes for the determination of some pharmaceutically-important nitro compounds”. 2023, Sci Rep 13, 5502. https://doi.org/10.1038/s41598-023-32494-8 (Q1, IF: 4.9).
• Amira S Gouda, Ahmed M Abdel-Megied, Mamdouh R Rezk, Hoda M Marzouk “LC-MS/MS-based metabolite quantitation of the antiviral prodrug baloxavir marboxil, a new therapy for acute uncomplicated influenza, in human plasma: Application to a human pharmacokinetic study” J Pharm Biomed Anal. 2023, 20, 115165. https://doi.org/10.1016/j.jpba.2022.115165 (Q2, IF: 3.4).
• Amira S Gouda, Hoda M Marzouk, Mamdouh R Rezk, Ahmed M Salem, Mosaad I Morsi, Eman G Nouman, Youmna M Abdallah, Ahmed Y Hassan, and Ahmed M Abdel-Megied “A validated LC-MS/MS method for determination of antiviral prodrug molnupiravir in human plasma and its application for a pharmacokinetic modeling study in healthy Egyptian volunteers.” J. Chromatography B. 2022, 1206, 123363. https://doi.org/10.1016/j.jchromb.2022.123363 (Q2, IF: 3.3).

Professional Affiliations & Memberships

• Royal Society of Chemistry (RSC)
• American Society of Mass Spectrometry (ASMS)
• American Association of Pharmaceutical Scientists (AAPS)
• American chemical Society (ACS)